Once you understand the causality of apoB meaning once you understand that apoB is not just associated with cardiovascular disease but it’s causally linked to it meaning it causes ASCVD…it makes no sense that we would look at a causal driver of ASCVD in the case of apoB and kind of take an approach of well being at the 20th percentile or the 30th percentile, the 40th percentile is acceptable. None of those things really make sense. – Dr. Peter Attia
Dr. Peter Attia, a preventive medicine expert and longevity specialist, delves into the intricate science of aging, cardiovascular disease, and cancer prevention.
He revelas valuable strategies for mastering longevity and enhancing overall health.
Table of Contents
- Understanding Cardiovascular Disease
- Cholesterol’s Dual Role
- The Functionality of Apolipoprotein B (APOB)
- Diet Management for Health Optimization
- Connection between Insulin Resistance and Heart Disease
- Evolutionary Biology’s Impact on Cholesterol Transportation
- Progression of Atherosclerosis
- Age and ApoB Levels
- Physiologic Levels of LDL Cholesterol
- Saturated Fat Consumption’s Effect on ApoB
- Standard Lab Reference Ranges for ApoB
- Cholesterol Synthesis and Reabsorption
Understanding Cardiovascular Disease
Cardiovascular disease is a leading cause of death worldwide that affects both sexes.
It typically involves plaque accumulation in coronary arteries which can limit blood flow to crucial heart muscles.
In severe cases where significant heart muscle becomes compromised, it could lead to sudden death or a heart attack.
Cholesterol’s Dual Role
Cholesterol plays a crucial role in cell fluidity and serves as a precursor for vital hormones like testosterone, estrogen, progesterone, and cortisol.
However, its transportation around the body requires packaging into water-soluble lipoproteins due to its water-insolubility.
