Maximize Protein Synthesis

Maximize Protein Synthesis

Under normal conditions, skeletal muscle has a high turnover rate – in the range of 1-2% of muscle proteins are being synthesized and broken down daily. Without the right nutrition at the right time, any potential muscle gain from increased protein synthesis could be canceled out by protein breakdown.

Protein Synthesis Primer: It’s All About mTOR

When you force a muscle to contract against a heavy load, the primary response is an activation of protein synthesis.

Post-workout

Muscle cells are primed for protein synthesis in the hours after training, but only if the right nutrition is there

The Case for Carbs

Studies have shown that insulin signaling isn’t needed to turn on training-induced protein synthesis – just leucine is required

Post-workout (up to 60 minutes after training) Protein Source: 30-50g fast-acting protein: whey isolates/ hydrolysates or casein hydrolysate

Carb Source: 25-75g of medium-to-low GI carbs

Pre-workout

During training, ATP is burned to fuel muscle contractions, which increases AMP levels.

Wrap-up

Nutrients have a potent effect on the protein synthetic machinery, and timing them right can make or break your training progress.

Peri-workout

Carbohydrates have been shown to inhibit protein degradation, and blunt AMPK mediated inhibition of mTOR.

How Much Protein?

Proteins act synergistically with weight training to stimulate protein synthesis, but there appears to be an upper limit to how much protein we can eat to max out protein synthesis.

References Baar K, Esser K.

Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol 1999;276:C120-C127

The “Anabolic Window”

There are three times for increasing protein/amino acid availability to augment the acute increase in protein synthesis caused by training

Pre-workout (30-60 minutes out) Protein Source: 30-50g of any medium to fast-acting protein source.

Whole-food is okay, but you may want to restrict whole-food protein closer to 60 minutes out than 30 minutes out.

Peri-workout: (during the workout) Protein Source: 10-20g of BCAAs or 20-30g of isolates / hydrolysates from casein or whey or a mixture like Plazma™ or MAG-10®

Carb Source: Optional. 35-50g of high glycemic carbs, sipped throughout the workout.

Source

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