What is PhenoAge and what is the science behind it?
It’s not the years you’ve been alive that’s actually the problem, it’s kind of how your body has changed over that time. And not everyone’s body changes in the same degree or at the same pace. – Dr. Morgan Levine
Dr. Morgan Levine discusses the science behind PhenoAge, a phenotypic aging clock she developed.
He delves into understanding the mechanisms that drive aging and age-related diseases with the objective of identifying potential interventions.
Table of Contents
- The Role of Epigenetic Aging Clocks
- Differentiating Biological and Chronological Age
- Advancements in Epigenetic Clocks
- Impact of Lifestyle and Environment on Aging
- Gender Disparities in Epigenetic Aging
- Correlation between Disease States and Epigenetic Aging
- The Interplay of Development and Aging
- Effects of Cancer Chemotherapy on Epigenetic Age
- Inflammation’s Role in Epigenetic Aging
- Intrinsic vs Extrinsic Aging Clocks
- Potential of Cellular Reprogramming
- Epigenetic Changes and Aging
The Role of Epigenetic Aging Clocks
Epigenetic aging clocks such as PhenoAge utilize bioinformatics to quantify the aging process by predicting chronological age based on DNA methylation patterns across multiple genomic sites.
However, these first-generation clocks have limitations in capturing physiological decline.
Differentiating Biological and Chronological Age
Chronological age refers to years lived, while biological age reflects changes in one’s body over time due to factors like lifestyle, genetics and environment.
Notably, biological age can vary significantly from chronological age as individuals’ bodies do not change at a uniform rate or manner.
